ESTIMATION OF MUCIN4 (MUC4) IN SALIVA OF HEALTH, PERIODONTITIS AND TYPE 2 DIABETES WITH PERIODONTITIS: A CROSSSECTIONAL COMPARATIVE STUDY.

Abstract

MUC4, a member of transmembrane mucin is expressed in body fluids like saliva, providing lubrication and protection of epithelial surfaces. Altered expression of MUC4 in saliva and GCF is noted in subjects with periodontitis. In diabetes there is decreased salivary flow causing oral alterations such as an increase in the concentration of mucin and glucose.To detect, estimate, compare and co-relate the levels of MUC4 in health, periodontitis and type 2 diabetes with periodontitis. Eighty subjects aged 25-55 years participated in this study and were divided into four groups with 20 subjects in each group. Group I: Systemically and periodontally healthy subjects Group II: Systemically healthy individuals with chronic periodontitis Group III : Diabetes with chronic periodontitis Group IV: Diabetes with healthy periodontium. A statistically significant difference,were observed when saliva levels of MUC4 from group I was compared to group II and group III, when group II was compared to group IV and also when group III was compared to group IV.