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http://172.16.16.104:8080/xmlui/handle/123456789/90
Title: | Log odds of positive lymph nodes as an independent predictor of overall survival in oral squamous cell carcinoma |
Authors: | Iyer, Varuni Kumar, Kiran Hallikeri, Kaveri Desai, Anil Kumar Kumar, Niranjan Natarajan, Srikant |
Issue Date: | 1-May-2020 |
Publisher: | Wolters Kluwer - Medknow |
Abstract: | category in major cancers. Literature is scarce concerning the prognostic ability of LODDS in oral squamous cell carcinoma (OSCC) patients. Aims: The present study was aimed toevaluate the importance of LODDS in predicting locoregional recurrence and overall survival (OS) in patients with OSCC compared to LNR. Settings and Design: The retrospectivestudy was carried out on 194 patients with OSCC cases treated by surgery ± adjuvant therapy from 2008 to 2014 at our institution. Subjects and Methods: Demographical andclinicopathological details of study cases were recorded. LNR and LODDS were calculated and expressed as a percentage and mean ± standard deviation. Statistical Analysis Used: The OS analysis was done by the Kaplan–Meier curve followed by log-rank (mantel-cox) test. Univariate and multivariate survival analysis was done to analyze the prognostic ability ofLNR% and LODDS after adjusting the clinicopathological parameters by the Cox proportional hazards model. Results: Patients with cut off values of LODDS >-1.2 and LNR% >4 hadsignificantly lower mean OS ( P = 0.001). Multivariate analysis indicated that only mean LODDS >-1.2 was significantly associated with poor OS. Although there was a correlation withlocoregional recurrence, LODDS and LNR failed to be the independent predictors of locoregional recurrence. Conclusions: LODDS was an independent reliable prognostic indicator forpatients with OSCCs than conventional staging systems and LNR. |
URI: | http://172.16.16.104:8080/xmlui/handle/123456789/90 |
Appears in Collections: | Log odds of positive lymph nodes as an independent predictor of overall survival in oral squamous cell carcinoma |
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